Insights Into Mucosal-Associated Invariant T Cell Biology From Studies of Invariant Natural Killer T Cells
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چکیده
منابع مشابه
Invariant Natural Killer T Cells
Invariant Natural killer T cell (iNKT cells) are a subset of T cells, which are narrowly defined as a T cell lineage expressing a semi-invariant CD1d-restricted T cell Receptors (TCRs) composed by Vα24-Jα18/Vβ11 in human, and Vα14-Jα18/Vβ8,Vβ7, and Vβ2 in mouse. Unlike conventional T cells which recognize peptides bound to highly polymorphic major histocompatibility complex (MHC) class I and II...
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Background: Invariant natural killer cells (iNKT) are an important immunoregulatory T cell subset. Currently several flow cytometry-based approaches exist for the identifi-cation of iNKT cells, which rely on using the 6B11 monoclonal antibody or a combina-tion of anti-Vα24 and anti-Vβ11 antibodies. Objective: The aim of this study was to compare the ability of two flow cytometry-based methods f...
متن کاملmucosal-associated invariant T cells
© 2008 Huang et al. The Rockefeller University Press $30.00 J. Exp. Med. Vol. 205 No. 5 1201-1211 www.jem.org/cgi/doi/ 1201 10.1084/jem.20072579 Mucosal-associated invariant T cells (MAITs) are a unique “ innate ” T cell population that expresses an invariant mV 19 TCR in mice and the homologous hV 7.2 in humans ( 1 ). With the exception of preferential localization in the intestine, MAIT cell...
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Background and Aims: Mucosal-associated invariant T (MAIT) cells are striking lymphocyte population in the blood and their importance in immune responses is growing fast. The current study was conducted to evaluate leptin hormone effects on MAIT cell functions. Materials and Methods: Five healthy male donors in ages of 22-30 years were selected and peripheral blood mononuclear cells (PBMCs) ...
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Coeliac disease is a chronic small intestinal immune-mediated enteropathy precipitated by exposure to dietary gluten in genetically predisposed individuals. The only current therapy is a lifelong gluten free diet. While much work has focused on the gliadin-specific adaptive immune response in coeliac disease, little is understood about the involvement of the innate immune system. Here we used m...
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ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2018
ISSN: 1664-3224
DOI: 10.3389/fimmu.2018.01478